Clobetasol Propionate, Neomycin, and Miconazole Cream is a combination cream which is applied topically to treat a variety of skin infections, including bacterial and fungal skin infections. A steroid drug called clobetasol propionate helps to lessen itching and inflammation. An antibiotic called neomycin is used to treat bacterial infections. An antifungal drug called miconazole is used to treat fungus infections. Clobetasol Propionate, Neomycin, and Miconazole Cream is very economical to use. Two to three times a day, or as instructed by a healthcare professional, the cream is applied to the affected area.